Article

Efficient removal of antibodies to adeno-associated viruses by immunoadsorption

2022-06-22

Abstract excerpt

Gene therapies based on adeno-associated viruses (AAV) are a therapeutic option to successfully treat monogenetic diseases. However, the influence of pre-existing immunity to AAV can compromise the application of AAV gene therapy, most notably by the presence of neutralizing antibodies to AAV. In the following study we investigated to what extent the treatment by immunoadsorption (IA) would reduce the levels of hu...

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Literature Corpus work: 5f0c8c3e-7edf-5bf1-b760-a3b7ea1cf7b5
DOI: 10.21203/rs.3.rs-1750719/v1

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