Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice

25 Oct 2010

Abstract excerpt

Rapamycin was administered in food to genetically heterogeneous mice from the age of 9 months and produced significant increases in life span, including maximum life span, at each of three test sites. Median survival was extended by an average of 10% in males and 18% in females. Rapamycin attenuated age-associated decline in spontaneous activity in males but not in females. Causes of death were similar in control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetics, Aging, and Longevity in Model Organisms
Share to Muscle Physiology and Disorders
Share to Sirtuins and Resveratrol in Medicine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20974732
DOI: 10.1093/gerona/glq178

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous MicePMID 20974732Read ↗

Rapamycin extends murine lifespan but has limited effects on aging.Semantic proximity Read ↗

Resveratrol and rapamycin: are they anti‐aging drugs?Semantic proximity Read ↗

Short term treatment with a cocktail of rapamycin, acarbose and phenylbutyrate delays aging phenotypes in mice.Semantic proximity Read ↗

Drugs, Nutrients, and Phytoactive Principles Improving the Health Span of Rodent Models of Human Age-Related DiseasesSemantic proximity Read ↗

Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young MiceSemantic proximity Read ↗

Dietary restriction and the pursuit of effective mimetics.Semantic proximity Read ↗

A combination of the geroprotectors trametinib and rapamycin is more effective than either drug aloneSemantic proximity Read ↗

Rapamycin Reverses the Hepatic Response to Diet-Induced Metabolic Stress That Is Amplified by AgingSemantic proximity Read ↗

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive.Semantic proximity Read ↗

Rapamycin extends maximal lifespan in cancer-prone mice.Semantic proximity Read ↗

The Role of mTOR Signaling in Controlling Mammalian Life Span: What a Fungicide Teaches Us About LongevitySemantic proximity Read ↗

Manipulation of health span and function by dietary caloric restriction mimeticsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.