Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Predictors of Hepatitis B Cure Using Gene Therapy to Deliver DNA Cleavage Enzymes: A Mathematical Modeling Approach

4 Jul 2013

Abstract excerpt

Most chronic viral infections are managed with small molecule therapies that inhibit replication but are not curative because non-replicating viral forms can persist despite decades of suppressive treatment. There are therefore numerous strategies in development to eradicate all non-replicating viruses from the body. We are currently engineering DNA cleavage enzymes that specifically target hepatitis B virus...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis B Virus Studies
Share to HIV Research and Treatment
Share to RNA Interference and Gene Delivery

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23861664
DOI: 10.1371/journal.pcbi.1003131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Predictors of Hepatitis B Cure Using Gene Therapy to Deliver DNA Cleavage Enzymes: A Mathematical Modeling ApproachPMID 23861664Read ↗

Zinc-finger Nucleases as a Novel Therapeutic Strategy for Targeting Hepatitis B Virus DNAsSemantic proximity Read ↗

AAV-Mediated Delivery of Zinc Finger Nucleases Targeting Hepatitis B Virus Inhibits Active ReplicationSemantic proximity Read ↗

Gene Therapy for Chronic HBV—Can We Eliminate cccDNA?Semantic proximity Read ↗

Progress With Developing Use of Gene Editing To Cure Chronic Infection With Hepatitis B Virus.Semantic proximity Read ↗

CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virusSemantic proximity Read ↗

Targeted DNA Mutagenesis for the Cure of Chronic Viral InfectionsSemantic proximity Read ↗

Gene-Editing and RNA Interference in Treating Hepatitis B: A ReviewSemantic proximity Read ↗

Classifying hepatitis B therapies with insights from covalently closed circular DNA dynamicsSemantic proximity Read ↗

An Efficient Antiviral Strategy for Targeting Hepatitis B Virus Genome Using Transcription Activator-Like Effector NucleasesSemantic proximity Read ↗

Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA.Semantic proximity Read ↗

Improved antiviral efficacy using TALEN-mediated homology directed recombination to introduce artificial primary miRNAs into DNA of hepatitis B virus.Semantic proximity Read ↗

Hepatitis B virus cccDNA is formed through distinct repair processes of each strandSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.