A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio.

doi:10.1530/JME-12-0185

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Article

A SULT2A1 genetic variant identified by GWAS as associated with low serum DHEAS does not impact on the actual DHEA/DHEAS ratio.

Journal of molecular endocrinology - 1 Feb 2013

Haring Robin, Wallaschofski Henri, Teumer Alexander, Kroemer Heyo, Taylor Angela E, Shackleton Cedric H L, Nauck Matthias, Völker Uwe, Homuth Georg, Arlt Wiebke

Abstract excerpt

DHEA is the major precursor of human sex steroid synthesis and is inactivated via sulfonation to DHEAS. A previous genome-wide association study related the single nucleotide polymorphism (SNP) rs2637125, located near the coding region of DHEA sulfotransferase, SULT2A1, to serum DHEAS concentrations. However, the functional relevance of this SNP with regard to DHEA sulfonation is unknown. Using data from 3300...

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PMID: 23132913
DOI: 10.1530/JME-12-0185
PMCID: PMC3535724

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