Genome-wide association analysis accounting for environmental factors through propensity-score matching: application to stressful live events in major depressive disorder.

doi:10.1002/ajmg.b.32180

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Article

Genome-wide association analysis accounting for environmental factors through propensity-score matching: application to stressful live events in major depressive disorder.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Sept 2013

Power Robert A, Cohen-Woods Sarah, Ng Mandy Y, Butler Amy W, Craddock Nick, Korszun Ania, Jones Lisa, Jones Ian, Gill Michael, Rice John P, Maier Wolfgang, Zobel Astrid, Mors Ole, Placentino Anna, Rietschel Marcella, Aitchison Katherine J, Tozzi Federica, Muglia Pierandrea, Breen Gerome, Farmer Anne E, McGuffin Peter, Lewis Cathryn M, Uher Rudolf

Abstract excerpt

Stressful life events are an established trigger for depression and may contribute to the heterogeneity within genome-wide association analyses. With depression cases showing an excess of exposure to stressful events compared to controls, there is difficulty in distinguishing between "true" cases and a "normal" response to a stressful environment. This potential contamination of cases, and that from genetically...

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PMID: 23857890
DOI: 10.1002/ajmg.b.32180

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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