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Endothelial cell‐derived bone morphogenetic proteins regulate glial differentiation of cortical progenitors

31 Mar 2008

Abstract excerpt

Gliogenesis is an important component of cortical development during the postnatal period. Two macroglial cells are generated in a particular order, i.e. astrocytes first and oligodendrocytes later. The mechanisms underlying this sequence of glial differentiation are unknown but interactions with blood vessels are postulated to play a role. We show, using a mouse in-vitro coculture system, that endothelial cells...

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PMID: 18380662
DOI: 10.1111/j.1460-9568.2008.06134.x

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