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Article

Airway basal cells of healthy smokers express an embryonic stem cell signature relevant to lung cancer.

Stem cells (Dayton, Ohio) - 1 Sept 2013

Shaykhiev Renat, Wang Rui, Zwick Rachel K, Hackett Neil R, Leung Roland, Moore Malcolm A S, Sima Camelia S, Chao Ion Wa, Downey Robert J, Strulovici-Barel Yael, Salit Jacqueline, Crystal Ronald G

Abstract excerpt

Activation of the human embryonic stem cell (hESC) signature genes has been observed in various epithelial cancers. In this study, we found that the hESC signature is selectively induced in the airway basal stem/progenitor cell population of healthy smokers (BC-S), with a pattern similar to that...

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Identifiers

PMID: 23857717
DOI: 10.1002/stem.1459
PMCID: PMC4051142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23857717-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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