Article
In search of low-frequency and rare variants affecting complex traits.
Human molecular genetics - 15 Oct 2013
Panoutsopoulou Kalliope, Tachmazidou Ioanna, Zeggini Eleftheria
Abstract excerpt
The allelic architecture of complex traits is likely to be underpinned by a combination of multiple common frequency and rare variants. Targeted genotyping arrays and next-generation sequencing technologies at the whole-genome sequencing (WGS) and whole-exome scales (WES) are increasingly employed to access sequence variation across the full minor allele frequency (MAF) spectrum. Different study design strategies...
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