Article
Measuring ribavirin concentrations during the earliest stages of antiviral therapy for hepatitis C: potential relevance for treatment outcome.
Therapeutic drug monitoring - 1 Aug 2013
van Vlerken Lotte G, de Kanter Clara T M M, Boland Greet J, van Loon Anton M, van Soest Hanneke, Koek Ger H, Drenth Joost P H, Siersema Peter D, van Erpecum Karel J, Burger David M
Abstract excerpt
BACKGROUND: Correlations between ribavirin (RBV) concentrations and sustained virological response (SVR) to hepatitis C virus treatment have been demonstrated previously. As steady state is reached after several weeks of RBV treatment, dose modifications based on steady-state levels can only be applied relatively late in treatment, possibly too late to influence SVR rates. The authors aimed to determine whether...
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