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Article

A CLCNKA polymorphism (rs10927887; p.Arg83Gly) previously linked to heart failure is associated with the estimated glomerular filtration rate in the RENASTUR cohort.

Gene - 25 Sept 2013

Tavira Beatriz, Gómez Juan, Ortega Francisco, Tranche Salvador, Díaz-Corte Carmen, Alvarez Francisco, Ortiz Alberto, Santos Fernando, Sánchez-Niño María D, Coto Eliecer

Abstract excerpt

A total of 569 individuals aged 55-85 and Caucasian were genotyped for SNP rs10927887 in the Ka renal chloride channel gene (CLCNKA). The following variables were significantly associated with an estimated glomerular filtration rate of (eGFR) <60 ml/min./1.73 m(2): age, type 2 diabetes, total cholesterol, LDL-cholesterol, and the CLCNKA GG genotype (p=0.03; OR=1.65, 95% CI=1.04-2.62). This novel finding could...

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Source

Identifiers

PMID: 23850580
DOI: 10.1016/j.gene.2013.06.055

Genes

CLCNKA

Variants

rs10927887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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