Identification of an overprinting gene in Merkel cell polyomavirus provides evolutionary insight into the birth of viral genes

Abstract excerpt

Many viruses use overprinting (alternate reading frame utilization) as a means to increase protein diversity in genomes severely constrained by size. However, the evolutionary steps that facilitate the de novo generation of a novel protein within an ancestral ORF have remained poorly characterized. Here, we describe the identification of an overprinting gene, expressed from an Alternate frame of the Large T Open...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Full-Duplex Wireless Communications
• Share to Plant Virus Research Studies
• Share to Polyomavirus and related diseases