Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Curcumin facilitates a transitory cellular stress response in Trembler-J mice.

Human molecular genetics - 1 Dec 2013

Okamoto Yuji, Pehlivan Davut, Wiszniewski Wojciech, Beck Christine R, Snipes G Jackson, Lupski James R, Khajavi Mehrdad

Abstract excerpt

We have previously shown that oral administration of curcumin significantly decreases the percentage of apoptotic Schwann cells and partially mitigates the severe neuropathy phenotype of the Trembler-J (Tr-J) mouse model in a dose-dependent manner. Here we compared the gene expression in sciatic nerves of 2-week-old pups and adult Tr-J with the same age groups of wild-type mice and found a significant increase in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anti-Inflammatory Agents, Non-Steroidal
Share to Curcumin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Stress

Share to HSP70 Heat-Shock Proteins

Share to Myelin Proteins

Share to Peripheral Nervous System Diseases

Share to Sciatic Nerve

Share to Unfolded Protein Response

Source

Open in PubMed Open full text

Identifiers

PMID: 23847051
DOI: 10.1093/hmg/ddt318
PMCID: PMC3820132

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Curcumin facilitates a transitory cellular stress response in Trembler-J mice.PMID 23847051Read ↗

Curcumin derivatives promote Schwann cell differentiation and improve neuropathy in R98C CMT1B mice.Semantic proximity Read ↗

Curcumin and Ethanol Effects in Trembler-J Schwann Cell CultureSemantic proximity Read ↗

Activation of XBP1s attenuates disease severity in models of proteotoxic Charcot-Marie-Tooth type 1BSemantic proximity Read ↗

MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth disease type 1B.Semantic proximity Read ↗

Treatment with IFB-088 improves neuropathy in CMT1A and CMT1B miceSemantic proximity Read ↗

Modulation of rumpshaker phenotype with wild-type PLP/DM20 suggests several pathogenic mechanisms.Semantic proximity Read ↗

Functions and Therapeutic Potential of Extracellular Hsp60, Hsp70, and Hsp90 in Neuroinflammatory DisordersSemantic proximity Read ↗

Four glial cells regulate ER stress resistance and longevity via neuropeptide signaling in C. elegans.Semantic proximity Read ↗

Transcriptomics study of hippocampus in mice exposed to heat stress.Semantic proximity Read ↗

Stress-Driven Selective Neuronal Vulnerability in Charcot-Marie-Tooth Disease: From Prodromal Pathology to Therapeutic Implications.Semantic proximity Read ↗

Overexpression of CHOP in Myelinating Cells Does Not Confer a Significant Phenotype under Normal or Metabolic Stress Conditions.Semantic proximity Read ↗

Amyloid β Induces Hormetic-Like Effects Through Major Stress Pathways in a <i>C. elegans</i> Model of Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.