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Article

Overexpression of CHOP in Myelinating Cells Does Not Confer a Significant Phenotype under Normal or Metabolic Stress Conditions.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Jun 2016

Southwood Cherie M, Fykkolodziej Bozena, Maheras Kathleen J, Garshott Danielle M, Estill Molly, Fribley Andrew M, Gow Alexander

Abstract excerpt

UNLABELLED: The PKR-like endoplasmic reticulum kinase (PERK) pathway of the unfolded protein response (UPR) is protective against toxic accumulations of misfolded proteins in the endoplasmic reticulum, but is thought to drive cell death via the transcription factor, CHOP. However, in many cell types, CHOP is an obligate step in the PERK pathway, which frames the conundrum of a prosurvival pathway that kills...

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Identifiers

PMID: 27335410
DOI: 10.1523/JNEUROSCI.1118-15.2016
PMCID: PMC4916253

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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