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Article

Stress-Driven Selective Neuronal Vulnerability in Charcot-Marie-Tooth Disease: From Prodromal Pathology to Therapeutic Implications.

Cells - 31 Jan 2026

Pan Xianchao, Xie Jiming, Li Zhiyu, Xiang Yuemeng, Yu Yongzhen, Cai Qianqian, Xu Haidong, Wan Ying, Xing Juan

Abstract excerpt

Charcot-Marie-Tooth (CMT) disease represents the most prevalent inherited peripheral neuropathy with a broad range of clinical manifestations, inheritance patterns, and causative genes. The primary pathological hallmark is progressive degeneration, predominantly affecting sensory and motor neurons, leading to prominent sensory deficits and progressive motor impairments. While neuropathy-causing mutations in the...

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Identifiers

PMID: 41677634
DOI: 10.3390/cells15030271
PMCID: PMC12896986

Genes

HSPB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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