Article
Common variants in the ATM, BRCA1, BRCA2, CHEK2 and TP53 cancer susceptibility genes are unlikely to increase breast cancer risk.
Breast cancer research : BCR - 1 Jan 2007
Baynes Caroline, Healey Catherine S, Pooley Karen A, Scollen Serena, Luben Robert N, Thompson Deborah J, Pharoah Paul D P, Easton Douglas F, Ponder Bruce A J, Dunning Alison M
Abstract excerpt
INTRODUCTION: Certain rare, familial mutations in the ATM, BRCA1, BRCA2, CHEK2 or TP53 genes increase susceptibility to breast cancer but it has not, until now, been clear whether common polymorphic variants in the same genes also increase risk. METHODS: We have attempted a comprehensive, single nucleotide polymorphism (SNP)- and haplotype-tagging association study on each of these five genes in up to 4,474...
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