Article
Distinct roles for two histamine receptors (hclA and hclB) at the Drosophila photoreceptor synapse.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Jul 2008
Pantazis Antonios, Segaran Ashvina, Liu Che-Hsiung, Nikolaev Anton, Rister Jens, Thum Andreas S, Roeder Thomas, Semenov Eugene, Juusola Mikko, Hardie Roger C
Abstract excerpt
Histamine (HA) is the photoreceptor neurotransmitter in arthropods, directly gating chloride channels on large monopolar cells (LMCs), postsynaptic to photoreceptors in the lamina. Two histamine-gated channel genes that could contribute to this channel in Drosophila are hclA (also known as ort) and hclB (also known as hisCl1), both encoding novel members of the Cys-loop receptor superfamily. Drosophila S2 cells...
Topics
- Animals
- Cell Line
- Chloride Channels
- Drosophila
- Drosophila Proteins
- Mutation
- Nerve Tissue Proteins
- Neuroglia
- Optic Lobe, Nonmammalian
- Patch-Clamp Techniques