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Article

Altered ivermectin pharmacology and defective visual system in Drosophila mutants for histamine receptor HCLB.

Invertebrate neuroscience : IN - 1 Dec 2008

Yusein Shazie, Velikova Nadya, Kupenova Petia, Hardie Roger, Wolstenholme Adrian, Semenov Eugene

Abstract excerpt

The Drosophila gene hclB encodes a histamine-gated chloride channel, which can be activated by the neurotoxin ivermectin when expressed in vitro. We have identified two novel hclB mutants, carrying either a missense mutation (P293S, allele hclB (T1)) or a putative null mutation (W111*, allele hclB (T2)), as well as a novel splice form of the gene. In survival studies, hclB (T1) mutants were more sensitive to...

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PMID: 18839229
DOI: 10.1007/s10158-008-0078-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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