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Article

Using high-throughput sequencing to leverage surveillance of genetic diversity and oseltamivir resistance: a pilot study during the 2009 influenza A(H1N1) pandemic.

PloS one - 1 Jan 2013

Téllez-Sosa Juan, Rodríguez Mario Henry, Gómez-Barreto Rosa E, Valdovinos-Torres Humberto, Hidalgo Ana Cecilia, Cruz-Hervert Pablo, Luna René Santos, Carrillo-Valenzo Erik, Ramos Celso, García-García Lourdes, Martínez-Barnetche Jesús

Abstract excerpt

BACKGROUND: Influenza viruses display a high mutation rate and complex evolutionary patterns. Next-generation sequencing (NGS) has been widely used for qualitative and semi-quantitative assessment of genetic diversity in complex biological samples. The "deep sequencing" approach, enabled by the enormous throughput of current NGS platforms, allows the identification of rare genetic viral variants in targeted...

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Identifiers

PMID: 23843978
DOI: 10.1371/journal.pone.0067010
PMCID: PMC3699567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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