Article
Systematic correlation between spine plasticity and the anxiety/depression-like phenotype induced by corticosterone in mice.
Neuroreport - 21 Aug 2013
Wang Guohua, Cheng Yufang, Gong Meifang, Liang Baofang, Zhang Mingzi, Chen Yupin, Zhang Cong, Yuan Xin, Xu Jiangping
Abstract excerpt
Unraveling the pathophysiological basis for the development of and recovery from depression is a unique challenge. Dendritic plasticity has been reported to be involved in the development of depression. We modeled an anxiety/depression-like phenotype by chronic corticosterone exposure in mice and reversed this anxiety/depression-like phenotype by long-term treatment with fluoxetine (FLX). Spine density in the...
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