Article
Genetic background affects susceptibility to tumoral stem cell reprogramming.
Cell cycle (Georgetown, Tex.) - 1 Aug 2013
García-Ramírez Idoia, Ruiz-Roca Lucía, Martín-Lorenzo Alberto, Blanco Oscar, García-Cenador María Begoña, García-Criado Francisco Javier, Vicente-Dueñas Carolina, Sánchez-García Isidro
Abstract excerpt
The latest studies of the interactions between oncogenes and its target cell have shown that certain oncogenes may act as passengers to reprogram tissue-specific stem/progenitor cell into a malignant cancer stem cell state. In this study, we show that the genetic background influences this tumoral stem cell reprogramming capacity of the oncogenes using as a model the Sca1-BCRABLp210 mice, where the type of tumor...
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