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Article

Stem-cell driven cancer: "Hands-off" regulation of cancer development

1 May 2009

Abstract excerpt

A cancer dogma states that inactivation of oncogene(s) can cause cancer remission, implying that oncogenes are the Achilles' heel of cancers. This current "hands on" model of cancer has kept oncogenes firmly in focus as therapeutic targets and is in agreement with the fact that in human cancers all cancerous cells, with independence of the cellular heterogeneity existing within the tumor, carry the same oncogenic...

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PMID: 19279406
DOI: 10.4161/cc.8.9.8217

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