Article
Heterogeneous phenotype of human glioblastoma: in vitro study.
Cell biochemistry and function - 1 Mar 2014
Denysenko Tetyana, Gennero Luisa, Juenemann Carola, Morra Isabella, Masperi Paolo, Ceroni Vincenzo, Pragliola Antonella, Ponzetto Antonio, Melcarne Antonio
Abstract excerpt
Glioblastomas (GBMs) are the most lethal primary brain tumours. Increasing evidence shows that brain tumours contain the population of stem cells, so-called cancer stem cells (CSCs). Stem cell marker CD133 was reported to identify CSC population in GBM. Further studies have indicated that CD133 negative cells exhibiting similar properties and are able to initiate the tumour, self-renew and undergo multilineage...
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