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Article

Challenges of guarantee-time bias.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Aug 2013

Giobbie-Hurder Anita, Gelber Richard D, Regan Meredith M

Abstract excerpt

The potential for guarantee-time bias (GTB), also known as immortal time bias, exists whenever an analysis that is timed from enrollment or random assignment, such as disease-free or overall survival, is compared across groups defined by a classifying event occurring sometime during follow-up. The types of events associated with GTB are varied and may include the occurrence of objective disease response, onset of...

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Identifiers

PMID: 23835712
DOI: 10.1200/JCO.2013.49.5283
PMCID: PMC3732313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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