Article

Restricted mean survival time approach versus time-varying coefficient Cox model for quantifying treatment effect when hazards are non-proportional

2024-11-07

Abstract excerpt

<title>Abstract</title> <p>Background Although the Cox time-varying coefficient (TVC) model has been developed to address non-proportional hazard (PH), its use remains underexplored. Instead, the restricted mean survival time (RMST) has been widely used in non-PH settings to quantify treatment effects using life expectancy ratio (LER) and life expectancy difference (LED). Methods This study explores a novel ext...

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Literature Corpus work: e4c5e6fa-31b6-578f-a13f-a2ab9537fd30
DOI: 10.21203/rs.3.rs-5315655/v1

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