Article
Genetic variation in the ADIPOQ gene, adiponectin concentrations and risk of colorectal cancer: a Mendelian Randomization analysis using data from three large cohort studies.
European journal of epidemiology - 1 May 2017
Nimptsch Katharina, Song Mingyang, Aleksandrova Krasimira, Katsoulis Michail, Freisling Heinz, Jenab Mazda, Gunter Marc J, Tsilidis Konstantinos K, Weiderpass Elisabete, Bueno-De-Mesquita H Bas, Chong Dawn Q, Jensen Majken K, Wu Chunsen, Overvad Kim, Kühn Tilman, Barrdahl Myrto, Melander Olle, Jirström Karin, Peeters Petra H, Sieri Sabina, Panico Salvatore, Cross Amanda J, Riboli Elio, Van Guelpen Bethany, Myte Robin, Huerta José María, Rodriguez-Barranco Miguel, Quirós José Ramón, Dorronsoro Miren, Tjønneland Anne, Olsen Anja, Travis Ruth, Boutron-Ruault Marie-Christine, Carbonnel Franck, Severi Gianluca, Bonet Catalina, Palli Domenico, Janke Jürgen, Lee Young-Ae, Boeing Heiner, Giovannucci Edward L, Ogino Shuji, Fuchs Charles S, Rimm Eric, Wu Kana, Chan Andrew T, Pischon Tobias
Abstract excerpt
Higher levels of circulating adiponectin have been related to lower risk of colorectal cancer in several prospective cohort studies, but it remains unclear whether this association may be causal. We aimed to improve causal inference in a Mendelian Randomization meta-analysis using nested case-control studies of the European Prospective Investigation into Cancer and Nutrition (EPIC, 623 cases, 623 matched...
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