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Article

Metabolic alterations due to caloric restriction and every other day feeding in normal and growth hormone receptor knockout mice.

The journals of gerontology. Series A, Biological sciences and medical sciences - 1 Jan 2014

Westbrook Reyhan, Bonkowski Michael S, Arum Oge, Strader April D, Bartke Andrzej

Abstract excerpt

Mutations causing decreased somatotrophic signaling are known to increase insulin sensitivity and extend life span in mammals. Caloric restriction and every other day (EOD) dietary regimens are associated with similar improvements to insulin signaling and longevity in normal mice; however, these interventions fail to increase insulin sensitivity or life span in growth hormone receptor knockout (GHRKO) mice. To...

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Source

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Identifiers

PMID: 23833202
DOI: 10.1093/gerona/glt080
PMCID: PMC3859362

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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