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Article

JadR and jadR2 act synergistically to repress jadomycin biosynthesis.

Science China. Life sciences - 1 Jul 2013

Zhang Yanyan, Zou Zhengzhong, Niu Guoqing, Tan Huarong

Abstract excerpt

The biosynthesis of antibiotics is controlled by cascade regulation involving cluster-situated regulators (CSRs) and pleiotropic regulators. Three CSRs have been identified in the jadomycin biosynthetic gene cluster, including one OmpR-type activator (JadR1) and two TetR-like repressors (JadR and JadR2). To examine their interactions in jadomycin biosynthesis, a series of mutants were generated and tested for...

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PMID: 23832247
DOI: 10.1007/s11427-013-4508-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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