Article
Impact of the proton pump inhibitors and CYP2C19*2 polymorphism on platelet response to clopidogrel as assessed by four platelet function assays.
Thrombosis research - 1 Aug 2013
Tsantes Argirios E, Ikonomidis Ignatios, Papadakis Ioannis, Bonovas Stefanos, Gialeraki Argiri, Kottaridi Christine, Kyriakou Elias, Kokori Styliani, Douramani Panagiota, Kopterides Petros, Karakitsos Petros, Lekakis John, Kapsimali Violetta
Abstract excerpt
BACKGROUND: Previous studies suggested a possible negative interference of proton pump inhibitors (PPIs) on clopidogrel's antiplatelet effect because of the competitive inhibition of the CYP 2C19 isoenzyme. Moreover, carriers of the loss-of-function allele of CYP2C19 polymorphism (CYP2C19*2) disp...
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