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Article

CYP2C19 genetic polymorphism, rabeprazole and esomeprazole have no effect on the antiplatelet action of clopidogrel.

Journal of cardiovascular pharmacology - 1 Jul 2013

El-Halabi Mustapha M, Zgheib Nathalie, Mansour Nabil M, Malli Ahmad, Ghaith Ola A, Mahfouz Rami, Alam Samir, Sharara Ala I

Abstract excerpt

The aim of this study is to investigate the effect of CYP2C19 polymorphism and cotherapy with rabeprazole or esomeprazole on the antiplatelet effect of clopidogrel. Patients receiving clopidogrel 75 mg ± rabeprazole or esomeprazole underwent genotyping for CYP2C19*2 and CYP2C19*3, and vasodilator-stimulated phosphoprotein testing to measure platelet reactivity index (PRI). Two hundred thirty-nine consecutive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 23474843
DOI: 10.1097/FJC.0b013e31828ecf44

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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