Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells.

Acta diabetologica - 1 Apr 2014

Locke Jonathan M, Lango Allen Hana, Harries Lorna W

Abstract excerpt

Changes in the levels of specific microRNAs (miRNAs) can reduce glucose-stimulated insulin secretion and increase beta-cell apoptosis, two causes of islet dysfunction and progression to type 2 diabetes. Studies have shown that single nucleotide polymorphisms (SNPs) within miRNA genes can affect t...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Type 2
Share to HeLa Cells
Share to Insulin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Insulin-Secreting Cells

Share to Insulin Secretion

Share to MicroRNAs

Share to Real-Time Polymerase Chain Reaction

Source

Open in PubMed Open full text

Identifiers

PMID: 23828613
DOI: 10.1007/s00592-013-0499-1
PMCID: PMC3969511

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23828613-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

A rare SNP in pre-miR-34a is associated with increased levels of miR-34a in pancreatic beta cells.PMID 23828613Read ↗

MicroRNA Expression in Alpha and Beta Cells of Human Pancreatic IsletsSemantic proximity Read ↗

Alteration of processing induced by a single nucleotide polymorphism in pri-miR-126.Semantic proximity Read ↗

Micro-RNA Binding Site Polymorphisms in the WFS1 Gene Are Risk Factors of Diabetes Mellitus.Semantic proximity Read ↗

miR-296-3p, miR-298-5p and their downstream networks are causally involved in the higher resistance of mammalian pancreatic α cells to cytokine-induced apoptosis as compared to β cellsSemantic proximity Read ↗

MicroRNA-mediated regulation of gene expression is affected by disease-associated SNPs within the 3'-UTR via altered RNA structure.Semantic proximity Read ↗

Spontaneous single nucleotide polymorphism in porcine microRNA-378 seed region leads to functional alteration.Semantic proximity Read ↗

MicroRNA polymorphisms: the future of pharmacogenomics, molecular epidemiology and individualized medicine.Semantic proximity Read ↗

Single-nucleotide polymorphisms among microRNA: big effects on cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.