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Targeting cancer stem cells expressing an embryonic signature with anti-proteases to decrease their tumor potential

4 Jul 2013

Abstract excerpt

Cancer stem cells (CSCs) are a specific subset of cancer cells that sustain tumor growth and dissemination. They might represent a significant treatment target to reduce malignant progression and prevent tumor recurrence. In solid tumors, several hierarchically organized CSC clones coexist, even within a single tumor. Among them, CSCs displaying an embryonic stem cell 'stemness' signature, based on the expression...

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PMID: 23828569
DOI: 10.1038/cddis.2013.206

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