Article
A Novel Oncolytic Herpes Capable of Cell-Specific Transcriptional Targeting of CD133± Cancer Cells Induces Significant Tumor Regression.
Stem cells (Dayton, Ohio) - 1 Aug 2018
Terai Kaoru, Bi Danse, Liu Zhengian, Kimura Kyle, Sanaat Zohreh, Dolatkhah Roya, Soleimani Mina, Jones Christopher, Bright Allison, Esfandyari Tuba, Farassati Faris
Abstract excerpt
The topic of cancer stem cells (CSCs) is of significant importance due to its implications in our understanding of the tumor biology as well as the development of novel cancer therapeutics. However, the question of whether targeting CSCs can hamper the growth of tumors remains mainly unanswered due to the lack of specific agents for this purpose. To address this issue, we have developed the first mutated version...
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