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Article

Mutational analysis of the binding pockets of the diketo acid inhibitor L-742,001 in the influenza virus PA endonuclease.

Journal of virology - 1 Oct 2013

Stevaert Annelies, Dallocchio Roberto, Dessì Alessandro, Pala Nicolino, Rogolino Dominga, Sechi Mario, Naesens Lieve

Abstract excerpt

The influenza virus PA endonuclease, which cleaves capped host pre-mRNAs to initiate synthesis of viral mRNA, is a prime target for antiviral therapy. The diketo acid compound L-742,001 was previously identified as a potent inhibitor of the influenza virus endonuclease reaction, but information on its precise binding mode to PA or potential resistance profile is limited. Computer-assisted docking of L-742,001...

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Identifiers

PMID: 23824822
DOI: 10.1128/JVI.00832-13
PMCID: PMC3807387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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