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Impaired host shutoff is a fitness cost associated with baloxavir marboxil resistance mutations in influenza A virus PA/PA-X nuclease domain

2025-09-22

Abstract excerpt

<h4>ABSTRACT</h4> The polymerase acidic (PA) protein is a subunit of the trimeric influenza A virus (IAV) RNA-dependent RNA polymerase and the target of the anti-influenza drug baloxavir marboxil (BXM). As with other direct-acting antivirals, treatment with BXM can lead to selection of viruses carrying resistance mutations. If these mutations have negligible fitness costs, resistant viruses can spread widely and...

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Identifiers and source

Literature Corpus work
6966c181-5132-5449-b568-ae6f80e22330
DOI
10.1101/2025.09.22.677688
Open publication

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Impaired host shutoff is a fitness cost associated with baloxavir marboxil resistance mutations in influenza A virus PA/PA-X nuclease domainDOI 10.1101/2025.09.22.677688
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