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Article

A kinetic test characterizes kinase intramolecular and intermolecular autophosphorylation mechanisms.

Science signaling - 2 Jul 2013

Dodson Charlotte A, Yeoh Sharon, Haq Tamanna, Bayliss Richard

Abstract excerpt

Many protein kinases catalyze their own activation by autophosphorylation. The mechanism of this is generally considered to be intermolecular and similar to that used in substrate phosphorylation. We derived the kinetic signatures of the four simplest autophosphorylation reactions and developed a test to determine the autoactivation mechanism of individual kinases. Whereas autophosphorylation of Nek7 and Plk4...

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Source

Identifiers

PMID: 23821772
DOI: 10.1126/scisignal.2003910

Genes

TPX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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