Article
Multiscale modeling of the causal functional roles of nsSNPs in a genome-wide association study: application to hypoxia.
BMC genomics - 1 Jan 2013
Xie Li, Ng Clara, Ali Thahmina, Valencia Raoul, Ferreira Barbara L, Xue Vincent, Tanweer Maliha, Zhou Dan, Haddad Gabriel G, Bourne Philip E, Xie Lei
Abstract excerpt
BACKGROUND: It is a great challenge of modern biology to determine the functional roles of non-synonymous Single Nucleotide Polymorphisms (nsSNPs) on complex phenotypes. Statistical and machine learning techniques establish correlations between genotype and phenotype, but may fail to infer the biologically relevant mechanisms. The emerging paradigm of Network-based Association Studies aims to address this problem...
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