Article
Two independent pathways of regulated necrosis mediate ischemia-reperfusion injury.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jul 2013
Linkermann Andreas, Bräsen Jan Hinrich, Darding Maurice, Jin Mi Kyung, Sanz Ana B, Heller Jan-Ole, De Zen Federica, Weinlich Ricardo, Ortiz Alberto, Walczak Henning, Weinberg Joel M, Green Douglas R, Kunzendorf Ulrich, Krautwald Stefan
Abstract excerpt
Regulated necrosis (RN) may result from cyclophilin (Cyp)D-mediated mitochondrial permeability transition (MPT) and receptor-interacting protein kinase (RIPK)1-mediated necroptosis, but it is currently unclear whether there is one common pathway in which CypD and RIPK1 act in or whether separate RN pathways exist. Here, we demonstrate that necroptosis in ischemia-reperfusion injury (IRI) in mice occurs as primary...
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