Article
The association of MDR1 C3435T and G2677T/A polymorphisms with plasma platelet-activating factor levels and coronary artery disease risk in Turkish population.
Gene - 15 Sept 2013
Ayaz Gulsel, Batar Bahadir, Kanigur Gonul, Guven Mehmet, Onaran Ilhan, Karadag Bilgehan, Ilerigelen Baris, Dirican Ahmet, Ulutin Turgut
Abstract excerpt
Increased levels of peripheral proinflammatory mediators can contribute to the development of coronary artery disease (CAD). Platelet activating factor (PAF) is an important proinflammatory mediator and plasma levels of PAF correlate with transmembrane transporter multidrug resistant 1 P-glycoprotein (MDR1 Pgp) expression and activity. MDR1 polymorphisms can affect the expression and activity of Pgp and plasma...
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