Article
PTP1B contributes to calreticulin-induced metastatic phenotypes in esophageal squamous cell carcinoma.
Molecular cancer research : MCR - 1 Sept 2013
Wang Xiao-Min, Shang Li, Zhang Yu, Hao Jia-Jie, Shi Feng, Luo Wei, Zhang Tong-Tong, Wang Bo-Shi, Yang Yang, Liu Zhi-Hua, Zhan Qi-Min, Wang Ming-Rong
Abstract excerpt
UNLABELLED: Calreticulin (CRT) is a Ca(2+)-binding chaperone protein that alters cellular Ca(2+)-homeostasis in the endoplasmic reticulum (ER). Previously it was shown that CRT was overexpressed in esophageal squamous cell carcinoma (ESCC), and elevated CRT expression promoted the migration and invasion of ESCC cells. In the present study, the mechanisms underlying the role of CRT in esophageal carcinoma...
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