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Article

GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12

19 Oct 2021

Abstract excerpt

Neurotransmitter receptors are involved in cancer progression. Among them, the heterodimeric GABA B receptor, activated by the main inhibitory neurotransmitter GABA, is composed of the transmembrane GABA B1 and GABA B2 subunits. The oncogenic role of the isoform GABA B1e (GB 1e ) containing only the extracellular domain of GABA B1 remains unclear. We revealed that GB 1e is largely expressed in human breast cancer...

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PMID: 34778730
DOI: 10.1016/j.isci.2021.103311

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