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Article

Complement therapy in atypical haemolytic uraemic syndrome (aHUS)

28 Jun 2013

Abstract excerpt

Central to the pathogenesis of atypical haemolytic uraemic syndrome (aHUS) is over-activation of the alternative pathway of complement. Inherited defects in complement genes and autoantibodies against complement regulatory proteins have been described. The use of plasma exchange to replace non-functioning complement regulators and hyper-functional complement components in addition to the removal of...

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PMID: 23810412
DOI: 10.1016/j.molimm.2013.05.224

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