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Article

Eculizumab in atypical haemolytic-uraemic syndrome allows cessation of plasma exchange and dialysis

30 Jan 2012

Abstract excerpt

Disorders in complement regulation are a major cause of atypical haemolytic-uraemic syndrome (aHUS). Eculizumab, a monoclonal antibody targeting complement C5 and blocking the terminal complement cascade, should theoretically be useful in this disease, particularly when associated with specific complement pathway anomalies such as Factor H deficiency. Eculizumab is emerging as an effective treatment for...

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PMID: 26069744
DOI: 10.1093/ndtplus/sfr174

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