Article
[Expression of FLT3-ITD oncogene confers mice progenitor B-cells BAF3 sensitivity to the ribonuclease binase cytotoxic action].
Molekuliarnaia biologiia - 1 Jan 2000
Mit'kevich V A, Orlova N N, Petrushanko I Iu, Simonenko O V, Spirin P V, Prokofeva M M, Gornostaeva A S, Stocking C, Makarov A A, Prasolov V S
Abstract excerpt
Acute myeloid leukemia is the most common acute leukemia affecting adults, and its incidence increases with age. Along with chromosomal translocations in leukemic cells mutations in the genes of receptor tyrosine kinases KIT and FLT3 were found with a high frequency. Here we show that transgenic...
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