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Article

Reverse transcriptase backbone can alter the polymerization and RNase activities of non-nucleoside reverse transcriptase mutants K101E+G190S.

The Journal of general virology - 1 Oct 2013

Wang Jiong, Li Dongge, Bambara Robert A, Dykes Carrie

Abstract excerpt

Previous work by our group showed that human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) containing non-nucleoside RT inhibitor (NNRTI) drug resistance mutations has defects in RNase H activity as well as reduced amounts of RT protein in virions. These deficits correlate with replication fitness in the absence of NNRTIs. Viruses with the mutant combination K101E+G190S replicated better in the...

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Identifiers

PMID: 23804564
DOI: 10.1099/vir.0.054999-0
PMCID: PMC3785032

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