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Article

MiR-205 is downregulated in hereditary hemorrhagic telangiectasia and impairs TGF-beta signaling pathways in endothelial cells.

Angiogenesis - 1 Oct 2013

Tabruyn Sebastien P, Hansen Sylvain, Ojeda-Fernández Maria-Luisa, Bovy Nicolas, Zarrabeitia Roberto, Recio-Poveda Lucia, Bernabéu Carmelo, Martial Joseph A, Botella Luisa-Maria, Struman Ingrid

Abstract excerpt

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by arteriovenous malformations and hemorrhages. This vascular disease results mainly from mutations in 2 genes involved in the TGF-β pathway (ENG and ALK1) that are exclusively expressed by endothelial cells. The present study identified miR-27a and miR-205 as two circulating miRNAs differentially expressed in HHT...

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Share to Human Umbilical Vein Endothelial Cells
Share to Neovascularization, Pathologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligonucleotides, Antisense

Share to Receptors, Transforming Growth Factor beta

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Source

Identifiers

PMID: 23800974
DOI: 10.1007/s10456-013-9362-9

Genes

ENG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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