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Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1

1 Jun 2017

Abstract excerpt

MACC1 (Metastasis Associated in Colon Cancer 1) is a key driver and prognostic biomarker for cancer progression and metastasis in a large variety of solid tumor types, particularly colorectal cancer (CRC). However, no MACC1 inhibitors have been identified yet. Therefore, we aimed to target MACC1 expression using a luciferase reporter-based high-throughput screening with the ChemBioNet library of more than 30,000...

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PMID: 28570591
DOI: 10.1371/journal.pbio.2000784

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