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Overexpression of human telomerase reverse transcriptase promotes the motility and invasiveness of HepG2 cells in vitro

25 Jun 2013

Abstract excerpt

Recent studies have indicated that telomerase activity promotes cancer invasion and metastasis, but the underlying mechanism remains unclear. Several studies have shown that expression of exogenous human telomerase reverse transcriptase (hTERT) can promote motility and invasiveness among telomerase-negative tumor cells, and inhibition of endogenous telomerase activity can reduce invasiveness in tumor cells....

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PMID: 23799592
DOI: 10.3892/or.2013.2563

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