Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Nov 2013

Ding Deqiang, Xi Peng, Zhou Junzhi, Wang Miao, Cong Yu-Sheng

Abstract excerpt

Telomerase plays a pivotal role in the pathology of aging and cancer by controlling telomere length and integrity. However, accumulating evidence indicates that telomerase reverse transcriptase may have fundamental biological functions independent of its enzymatic activity in telomere maintenance. In this study, the ectopic expression of human telomerase reverse transcriptase (hTERT) and its catalytic mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Active Transport, Cell Nucleus
Share to HEK293 Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HeLa Cells

Share to Matrix Metalloproteinases

Share to MCF-7 Cells

Share to Telomerase

Share to Transcription Factor RelA

Share to Up-Regulation

Source

Identifiers

PMID: 23884427
DOI: 10.1096/fj.13-230904

Genes

MMP1
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human telomerase reverse transcriptase regulates MMP expression independently of telomerase activity via NF-κB-dependent transcription.PMID 23884427Read ↗

Role of telomerase in the tumour microenvironmentSemantic proximity Read ↗

Human telomerase reverse transcriptase (hTERT) promotes cancer invasion by modulating cathepsin D via early growth response (EGR)-1Semantic proximity Read ↗

hTERT promotes the invasion of telomerase-negative tumor cells in vitroSemantic proximity Read ↗

Transcriptional activation of hTERT through the NF-κB pathway in HTLV-I–transformed cellsSemantic proximity Read ↗

Overexpression of human telomerase reverse transcriptase promotes the motility and invasiveness of HepG2 cells in vitroSemantic proximity Read ↗

Human telomerase reverse transcriptase promotes the epithelial to mesenchymal transition in lung cancer cells by enhancing c-MET upregulationSemantic proximity Read ↗

Human Telomerase Reverse Transcriptase (hTERT) Is a Novel Target of the Wnt/β-Catenin Pathway in Human CancerSemantic proximity Read ↗

hTERT promotes cell adhesion and migration independent of telomerase activity.Semantic proximity Read ↗

Correlation of the expression of human telomerase subunits with telomerase activity in normal skin and skin tumorsSemantic proximity Read ↗

Chronic Exposure to Carbon Nanotubes Induces Invasion of Human Mesothelial Cells through Matrix Metalloproteinase-2Semantic proximity Read ↗

Telomerase Activation in Atherosclerosis and Induction of Telomerase Reverse Transcriptase Expression by Inflammatory Stimuli in MacrophagesSemantic proximity Read ↗

Overexpression of the telomerase holoenzyme induces EMT and tumorigenesis of HPV‐immortalized keratinocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.