Article
Genetic variant in MTRR, but not MTR, is associated with risk of congenital heart disease: an integrated meta-analysis.
PloS one - 1 Jan 2014
Cai Bingxi, Zhang Ti, Zhong Rong, Zou Li, Zhu Beibei, Chen Wei, Shen Na, Ke Juntao, Lou Jiao, Wang Zhenling, Sun Yu, Liu Lifeng, Song Ranran
Abstract excerpt
BACKGROUND: Congenital heart disease (CHD) is one of the most common birth defects and the leading cause of deaths among individuals with congenital structural abnormalities worldwide. Both Methionine synthase reductase (MTRR) and Methionine synthase (MTR) are key enzymes involved in the metabolic pathway of homocysteine, which are significant in the earlier period embryogenesis, particularly in the cardiac...
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