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Article

Two distinct regions in a yeast myosin-V tail domain are required for the movement of different cargoes.

The Journal of cell biology - 7 Aug 2000

Catlett N L, Duex J E, Tang F, Weisman L S

Abstract excerpt

The Saccharomyces cerevisiae myosin-V, Myo2p, is essential for polarized growth, most likely through transport of secretory vesicles to the developing bud. Myo2p is also required for vacuole movement, a process not essential for growth. The globular region of the myosin-V COOH-terminal tail domain is proposed to bind cargo. Through random mutagenesis of this globular tail, we isolated six new single point mutants...

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Share to Myosin Heavy Chains

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10931864
DOI: 10.1083/jcb.150.3.513
PMCID: PMC2175197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Two distinct regions in a yeast myosin-V tail domain are required for the movement of different cargoes.PMID 10931864Read ↗

The COOH-terminal domain of Myo2p, a yeast myosin V, has a direct role in secretory vesicle targeting.Semantic proximity Read ↗

Myosin V attachment to cargo requires the tight association of two functional subdomains.Semantic proximity Read ↗

Regulated phosphorylation of budding yeast's essential myosin V heavy chain, Myo2p.Semantic proximity Read ↗

The tail of a yeast class V myosin, myo2p, functions as a localization domain.Semantic proximity Read ↗

The Saccharomyces cerevisiae MYO2 gene encodes an essential myosin for vectorial transport of vesicles.Semantic proximity Read ↗

Head-to-tail regulation is critical for the in vivo function of myosin V.Semantic proximity Read ↗

The myosin-related motor protein Myo2 is an essential mediator of bud-directed mitochondrial movement in yeast.Semantic proximity Read ↗

Complex formation with Ypt11p, a rab-type small GTPase, is essential to facilitate the function of Myo2p, a class V myosin, in mitochondrial distribution in Saccharomyces cerevisiae.Semantic proximity Read ↗

Regulated degradation of a class V myosin receptor directs movement of the yeast vacuole.Semantic proximity Read ↗

Structural basis of cargo recognitions for class V myosins.Semantic proximity Read ↗

Kinesin-related Smy1 enhances the Rab-dependent association of myosin-V with secretory cargo.Semantic proximity Read ↗

A type V myosin (Myo2p) and a Rab-like G-protein (Ypt11p) are required for retention of newly inherited mitochondria in yeast cells during cell division.Semantic proximity Read ↗

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